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How can we address the controversies surrounding the use of non-steroidal anti-inflammatory drugs in neurodegeneration?

In this editorial, we propose a novel approach to address the controversies of using non-steroidal anti-inflammatory drugs (NSAIDs) to prevent neurodegenerative disorders (NDD), such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis.

Go to the profile of Alyza King
Jul 11, 2016

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Go to the profile of Ramaswamy Narayanan
Ramaswamy Narayanan over 1 year ago

Inflammation and inflammatory mediators are involved diverse dieseases. Many clinicians would agree that if one understands inflammation, it is possible to understand other diseases such as cancer, infection, cardiac and neurodegenerative diseases.. Cytokines and chemokines mediate imflammatory response and regulate AA , PGs and TXA2 pathways. The NSAIDs affect the balance between the pro and anti imflammatory cytokines. Thus it is reasonable to suppose that NSAIDs play an important role in diseases such as neurodegenerative diseases. The proposed study could shed light into the usefulness of the NSAIDs in single or combination therapy.