In silico functional elucidation of uncharacterized proteins of Chlamydia abortus strain LLG
New study characterizes hypothetical Chlamydia proteins
Chlamydia abortus causes abortion and fetal death in mammals, including humans, and thus development of new therapeutics is of interest the biomedical community.
The genome of C. abortus LLG has been sequenced, with several hypothetical proteins reported. Building on this, a new research article has been published in Future Science OA extracted hypothetical protein sequences from the C. abortus LLG Genome Database and performed functional elucidation using in silico methods.
The study highlighted 51 proteins as having a role in defense, binding and transport. 45 were non-homologous with the host, 31 of which were related to virulence.
The study went on to further determine the structure of two proteins with potential as drug targets.
Citation: In silico functional elucidation of uncharacterized proteins of Chlamydia abortus strain LLG. Gagandeep Singh, Dixit Sharma, Vikram Singh, Jyoti Rani, Francessco Marotta, Manoj Kumar, Gorakh Mal, Birbal Singh
Future Science OA FSO169, doi:10.4155/fsoa-2016-0066 (2017).