Designing nucleic acid-based drugs as antibacterial agents
New research demonstrates cyclic dinucleotides could compete with DNA and RNA for intercalator binding
Recent research by Herman O Sintim and colleagues from Purdue University & University of Maryland examines supramolecular polymer formation by cyclic dinucleotides and intercalators, and how they affect dinucleotide enzymatic processing. An interesting conclusion from the group is the discovery that cyclic dinucleotides may compete with DNA and RNA for intercalator binding. This point is particularly pertinent to medicinal chemists - the authors recommend this is born in mind when designing nucleic acid-based drugs as antibacterial agents.
Read the full piece (open access) in Future Science OA, here: http://www.future-science.com/doi/full/10.4155/fso.15.93
Supramolecular polymer formation by cyclic dinucleotides and intercalators affects dinucleotide enzymatic processing
Shizuka Nakayama, Jie Zhou, Yue Zheng, Henryk Szmacinski, Herman O Sintim
Future Science OA, FSO93, doi: 10.4155/fso.15.93 (2016).