Is there any article published on "Mathematics behind Pharmacophoric features" I mean mathematical values different groups/functional groups- feature of pharmacophore (HBD, HBA, Aromatic ring, etc.)

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VIRENDRA NATH SRIVASTAV on Aug 12, 2015 • 1 answer
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Yes, the book by Todeschine and Consonni provides an exhaustive theoretical and practical assessment of virtually any molecular descriptor in common usage:
http://onlinelibrary.wiley.com/book/10.1002/9783527613106

If you are focusing very narrowly on only those descriptors that are employed in pharmacophore characterization, then you may be able to hone in on an article that answers your question more immediately. I'm not certain of exactly what you mean by "mathematical values", but a comparison between the relative importance of specific pharmacophore features across different ligand classes is provided in the article by Zuccotto:

http://pubs.acs.org/doi/abs/10.1021/ci034068k

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Gerald Lushington on Aug 12, 2015
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