Drug delivery via porous silicon: a focused patent review
This patent review article brought to MedChemNet users by our sister journal Pharmaceutical Patent Analyst, provides a patent review for drug delivery methods based on porous silicon.
In this patent review, Paulina Kulyavtsev and Roxanne Spencer (Princeton International School of Mathematics & Science; Princeton, NJ, USA) explore the patenting activity for drug delivery methods based on porous silicon.
Although silicon is more commonly associated with computer chips than
with drug delivery, with the discovery that porous silicon is a viable
biocompatible material, mesoporous silicon with pores between 2 and 50
nm has been loaded with small molecule and biomolecule therapeutics and
safely implanted for controlled release. As porous silicon is readily
oxidized, porous silica must also be considered for drug delivery
applications. Since 2010, only a limited number of US patents have been
granted, primarily for ophthalmologic and immunotherapy applications, in
contrast to the growing body of technical literature in this area.
Read the full article here:
Kulyavtsev PA, Spencer RP. Drug delivery via porous silicon: a focused patent review. Pharm. Pat. Anal. 6(2), 77-85 (2017)